A One
Dose Future
Verve Therapeutics, a wholly owned subsidiary of Eli Lilly and Company, is on a mission to find a single-dose solution to lower your high cholesterol.
Our goal at Verve Therapeutics is to develop single-course treatments to help lower levels of low-density lipoprotein cholesterol (LDL-C) for many years, or possibly the rest of your life. Our innovative approach uses cutting-edge gene editing technology as a potential single course of treatment to lower LDL-C levels in the blood. You may be able to take part in a clinical trial for one of these investigational medicines.
Why should you participate?
Millions of people around the world have been impacted by cardiovascular disease caused by high levels of low-density lipoprotein cholesterol (LDL-C). Some conditions that cause high cholesterol are inherited, which means they are passed down from a parent to their child, resulting in many family members having high LDL-C levels. Many people make lifestyle changes and take cholesterol-lowering medications but still have high LDL-C levels, putting them at increased risk of having a heart attack or stroke. Lowering LDL-C levels in the blood is the best way to reduce these risks.
At Verve, we are committed to developing a new approach to address this unmet need. By taking part in a clinical trial you may help improve treatment options for others that have high LDL-C levels. Take the prescreener or click on one of our clinical trials below to learn more.
At Verve, we are committed to developing a new approach to address this unmet need. By taking part in a clinical trial you may help improve treatment options for others that have high LDL-C levels. Take the prescreener or click on one of our clinical trials below to learn more.
We are on a mission to protect the world from cardiovascular disease.
See if you prequalify
Answer a few questions to see if you prequalify for a clinical trial.
Your information is stored in a HIPAA-compliant database and provided to the trial sites for follow-up as appropriate. For further information, please see our privacy policy page.
See if you prequalify
Answer a few questions to see if you prequalify for a clinical trial.
Your information is stored in a HIPPA-compliant database and provided to the trial sites for follow-up as appropriate. For further information, please see our privacy policy page.
Information about our studies
The clinical trial team will explain the possible benefits and risks of participating
If you choose to participate in a clinical trial, you can stop participating at any time
You will be reimbursed for your time during participation
You will be reimbursed for travel and other expenses during participation
The clinical trial medication and clinical trial-related tests will be provided at no cost to participants
A team of doctors and nurses will monitor your health carefully during the clinical trial
The clinical trial has been cleared by an Institutional Review Board/Ethics Committee and national health authority, which protects the participants’ rights, safety, and well-being
We are committed to putting people first and developing medicines for cardiovascular disease.
Understanding cardiovascular health
Cardiovascular Disease, or CVD, includes a range of heart and blood vessel conditions that can lead to heart attack, stroke or other serious heart conditions. High cholesterol is one of the main causes of CVD.
Some risk factors that impact your heart health are things you cannot change:
- Age – CVD risk increases with age
- Race and ethnicity – Some groups may have higher risk of certain conditions such as diabetes, which increase the risk of CVD
- Genetics – family history and genetic conditions may increase risk of CVD
Others risk factors are changeable. Your risk of CVD may be reduced by lifestyle changes such as:
- Maintaining a healthy weight
- Exercising regularly
- Managing blood sugar levels
- Not smoking
- Following a heart healthy diet
- Managing blood pressure
- Getting enough sleep
Your body needs cholesterol, which is a type of fat (or lipid), because it helps your body perform many important functions. However, too much cholesterol in your blood is not good and can lead to CVD. If you have high cholesterol, you will usually not have symptoms until it causes an event such as a heart attack or stroke. That is why it is important to have your blood tested for lipid levels. This test is called a lipid profile or lipid panel. The results show the type and amount of cholesterol, and other lipids, in your blood, so you can monitor your levels over time.
About our clinical trials
Two clinical trials, sponsored by Verve Therapeutics, are available to eligible participants who seek to lower their low-density lipoprotein cholesterol (LDL-C) levels despite being on cholesterol-lowering medications. The trials are open-label Phase 1 single-ascending dose trials, meaning enrolled participants will only receive one dose of the investigational medicine and will know what dose they receive. The investigational medicine is given as a one-time, intravenous (IV) infusion into a vein in the arm with short inpatient stay following the infusion and a 12-month follow-up period to continue to monitor your health and LDL-C levels. After the end-of-study visit, you will continue to participate in a long-term follow-up study to monitor your safety and cholesterol levels. Many of these visits can be done from home. To learn more about these clinical trials, click on the links below.
The Heart-2 study is a clinical trial for people who have high levels of LDL-C despite being on cholesterol-lowering medicines and have been diagnosed with the following:
Heterozygous familial hypercholesterolemia (HeFH), an inherited condition that causes lifelong high LDL-C levels.
and/or
Premature coronary artery disease (CAD), which is a serious heart disease because of high cholesterol, occurring before the age of 65 in women or 55 in men.
The purpose of the Heart-2 study is to assess the safety and tolerability of the investigational medicine called VERVE-102 and see if it can help lower LDL-C levels with a single dose.
The Pulse-1 study is a clinical trial for people who have high levels of LDL-C despite being on cholesterol-lowering medicines and have been diagnosed with the following:
Heart disease, called atherosclerotic cardiovascular disease (ASCVD)
or
Severe hypercholesterolemia, which is very high cholesterol levels in the blood.
The purpose of the Pulse-1 study is to assess the safety and tolerability of the investigational medicine called VERVE-201 and see if it can help lower LDL-C levels with a single dose.
Understanding clinical trials
How new approved medicines are developed
Clinical trials are essential to ensure the safety and effectiveness of new medications and therapies. They test investigational medicines before they become available for healthcare providers to prescribe to their patients. Below we outline the typical phases of clinical trials and how each phase contributes to better understanding the safety, dosage, and effectiveness of the investigational medicines.
Phase
Purpose
Participants
Key Activities
- Evaluate safety and side effects
- Determine a safe dosage range
- Assess tolerability
- Evaluate effectiveness
- Evaluate safety and side effects
- Confirm dosage
- Confirm effectiveness
- Monitor adverse reactions
- Compare with standard treatments
- Collect long-term data
- Identify rare side effects
- Ensure ongoing safety
By understanding these phases, you can better appreciate the rigorous process that all approved medicines must go through prior to being available for prescribing by healthcare professionals. Participation in clinical trials is crucial in helping advance medical research and improve healthcare for everyone.
Heart is at the center of everything we do.